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Acid blockers increase the risk of death

Acid blockers increase the risk of death

Millions of people swallow them daily: the popular acid blockers (proton pump inhibitors). They are prescribed for heartburn and many other digestive problems. Also known as gastric protection, the pills are known. Because they are concomitantly prescribed when stomach-damaging drugs (such as analgesics or antibiotics) must be taken. The acid blockers, however, are anything but harmless. The list of their side effects is long. An increased risk of death was added (July 2017).

Acid blockers can almost completely stop gastric acid formation

Acid blockers of the proton pump inhibitor type are very commonly prescribed. Originally especially for serious gastrointestinal problems, such. As gastric bleeding, reflux disease or esophageal cancer, now in almost every stomach problem.

Who also longer term gastrointestinal drugs such. If, for example, certain antibiotics or NSRIs (anti-inflammatory analgesics, for example, in rheumatism) are used, the acid blocker is also prescribed - whether human, dog or cat.

However, acid blockers are also available (for short-term use and lower doses) freely available for sale, so they are not always subject to prescription, which increases their popularity even further. Many people resort to risky drugs even if they only have a little heartburn.

Proton pump inhibitors are often abbreviated PPI. These are agents containing the active substances omeprazole, pantoprazole, esomeprazole, etc. If your stomach medicine contains a substance with the ending -prazole, this is PPI.

In contrast to the antacids (eg Rennie), which "only" neutralize the gastric acid already formed, PPI directly in the cells of the gastric mucosa reduce the production of gastric acid. Therefore, they do not work immediately after intake, but only some time later. Often, PPIs not only reduce gastric acid secretion, they can almost bring it to a standstill.

Anyone who knows the importance of gastric acid for human health, at least now suspects what serious effects the acid blockers can have.

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Acid Blocker: Increased risk of dying and other side effects

PPIs are among the top 5 most widely prescribed and ingested medications in the developed world. In the US alone, Nexium is prescribed 15 million times a month (!).

However, it is not only the remedies themselves that are known, but also their many side effects, especially if they are taken long-term. Serious kidney damage is just as important as an increased bone fracture risk and possibly also dementia. Especially common are the following side effects:

  • PPIs can lead to gastrointestinal complaints: stomach depressions, bloating, nausea, diarrhea etc.
  • PPIs promote the development of food allergies.
  • PPIs can lead to a vitamin B12 deficiency and all its serious consequences.
  • PPIs can lead to absorption disorders, which means that the minerals and trace elements can no longer be fully absorbed from the intestine. It can therefore come to chronic nutrient deficiencies, z. B. to calcium, magnesium, iron and zinc deficiency.
  • With a calcium, magnesium and zinc deficiency, the risk of bone fracture increases again in older age.
  • After taking PPI for several weeks, the liver values ​​may deteriorate.
  • The risk of chronic kidney disease increases if PPIs are taken in the long term. Both types of acid blockers (both proton pump inhibitors and histamine receptor antagonists) can increasingly lead to kidney stones or other chronic kidney disease - such. For example, the two studies included in theKidney Weekof theAmerican Society of Nephrologypresented in Chicago in November 2016 and that you will find described here: Acid Blocker: Harmful to the kidneys
  • The risk of infection increases in the presence of PPI, d. H. the risk of pneumonia, salmonella infections, or the like, which would be warded off in a healthy immune system, becomes greater with PPI ingestion.
  • PPI promote the proliferation of Helicobacter pylori, the stomach germ responsible for gastritis and gastric ulcer. Natural measures against Helicobacter pylori: Probiotics against the stomach bacterium
  • If an expectant mother takes acid blockers during pregnancy, it can increase the risk of allergies to the child, adversely affect his immune system and, moreover, increase his risk of becoming an asthmatic, researchers at University of Edinburgh announced in January 2017.They found that children whose mothers were prescribed acid blockers during pregnancy were much more likely to suffer from asthma than children whose mothers had not taken these drugs.

However, this study was not about PPIs but histamine receptor antagonists. In any case, it is best if you do not have to take any acid blockers at all and can solve the problem in another way, especially as both drugs - PPIs and histamine receptor antagonists - have been considered safe drugs in pregnancy.

A new study of Washington University School of Medicine in St. Louis / Missouri now shows that the long-term use of PPIs is also associated with an increased risk of death. On 3 July 2017, the results were published in the journal BMJ Open released.

Acid Blocker: Risk of premature death increases by 50 percent

Researchers studied data from 275,000 PPI users and 75,000 people taking histamine receptor antagonists to reduce their gastric acidity.

Histamine receptor antagonists actually belong to the group of antihistamines. They are usually prescribed for allergies. However, since histamine receptors are also abundant in the gastric mucosa and these are involved in the production of gastric acid, histamine receptor antagonists provide for the inhibition of histamine receptors for a reduced formation of gastric acid.

However we turned and used the data, we always saw the same thing, namely an increased risk of death in people who took PPIs, "says study author Dr. Ziyad Al-Aly, a kidney specialist and assistant professor of medicine.
Comparing patients who used histamine receptor antagonists for one to two years compared to those who took PPI for as long, PPI users were at 50 percent more likely to die in the next five years. This disadvantage of PPI persisted even when we considered that PPI users in our study were mostly older and already suffering from chronic diseases. "

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The longer you take PPI, the more the side effects

Professor Al-Aly suggests that all the many different side effects of PPI in its entirety cause users to be weakened and therefore die earlier.

The research team also noted that those patients who took PPIs but did not have gastric distress (use as "gastric protection") had a 24 percent higher risk of dying compared to the histamine receptor antagonists.

The risk of dying prematurely from PPI episodes also increased the longer you took the medication.

Doctors prescribe PPI over and over again - although the patient would have to sell them long ago

Many people believe that PPIs are extraordinarily harmless, simply because they can be bought over the counter without prescription and doctors are also very quick with these funds. Normally you should not take PPI for more than two to eight weeks. But many people take them for years - and not least because their doctor does not tell them that they need to stop taking the medication on time. Yes, doctors often prescribe PPI on request again and again.

However, PPI is extremely risky if taken over the long term. Professor Al-Aly therefore emphasizes that it should be decided very carefully which patient and if any, PPIs are required.

PPI can save lives, "said Al-Aly." If I needed PPI, I would take it of course. But I would never just take it that way. If I had to swallow the drugs, I would expect my doctor to monitor me and my values ​​well and tell me immediately if I no longer need the medication. "

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PPI - How to make an acid blocker

The problem now is that PPI - once you get used to it, which can be the case after a few weeks - can not settle so easily. As soon as PPI is stopped, heartburn often returns more than ever before. And if you have never had heartburn (for example, because you took the remedy as "stomach protection" to another therapy), then you often get it thanks to PPI, as soon as the therapy is declared to be over or you forget to take the remedy.

Details on the side effects of PPIs listed above can be found here: The vicious circle of acid blockers, where we also described alternatives to the acid blockers or measures how to get out of the "addiction" to acid blockers.

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Acid blockers increase the risk of death

FAQ - 💬

❓ What are the long term effects of taking acid reducers?

👉 The most common side effects reported include headache, diarrhea, nausea, and vomiting. Reports of more serious side effects include kidney disease, fractures, infections and vitamin deficiencies, but these are very rare and are generally associated with long-term use (using these products for more than a year).

❓ What are the dangers of proton pump inhibitors?

👉 Although PPIs have had an encouraging safety profile, recent studies regarding the long-term use of PPI medications have noted potential adverse effects, including risk of fractures, pneumonia, Clostridium difficile diarrhea, hypomagnesemia, vitamin B12 deficiency, chronic kidney disease, and dementia.

❓ Can PPIs cause heart problems?

👉 Proton pump inhibitor use is independently associated with an increased incidence of heart failure and death. Proton pump inhibitors (PPIs) may increase the risk for heart failure and death, but not acute ischemic events, in patients with coronary artery disease (CAD), according to a study published in PLoS One.

❓ Are there any potential complications or effects from long term suppression therapy with PPIs?

👉 The long-term acid suppression by PPIs can also lead to enteric, respiratory and urinary tract infections. The hypochlorhydria by chronic PPIs use may induce hypergastrinemia, which ultimately mediates the gastric polyps, gastric carcinoids and gastric cancer.

❓ How long can you take acid blockers?

👉 Like any medication, patients should only use PPIs for as long as necessary to treat their underlying condition. “It is critically important that patients take their medications only as directed,” Chang said. “The FDA recommends that PPIs be administered over a four week course of treatment, three times a year.”

❓ What is the safest acid reducer to take?

👉

  • Best Overall: Pepto Bismol Original at Amazon. ...
  • Best Proton Pump Inhibitor: Prilosec OTC at Amazon. ...
  • Best Flavored Antacid: TUMS Chewy Bites Antacid Tablets at Amazon. ...
  • Best Chewable Antacid: Rolaids Extra Strength Antacid Chewable Tablets at Amazon. ...
  • Best for GERD: ...
  • Best for Kids: ...
  • Best With Added Benefits:
28 Jul 2022

❓ Who should not take proton pump inhibitors?

👉 PPIs have risks. Higher risk of kidney disease, or kidney disease that gets worse. A higher risk of heart attack. In people age 75 and older, a higher risk of dementia.

❓ Are H2 blockers safer than proton pump inhibitors?

👉 Histamine H2 receptor antagonists (H2RAs) are more cost-effective and safer compared with PPIs.

❓ Are H2 blockers safer than PPIs?

👉 If you had to choose between long-term PPI use or long-term H2 blocker use, the H2 blocker would be the safer bet. H2 blockers reduce stomach acidity to a much lesser extent while maintaining the stomach's ability to react to internal stimuli and change the acidity as needed.

❓ Can omeprazole cause heart attacks?

👉 There is some evidence that omeprazole or esomeprazole may prevent clopidogrel from working as effectively, leading to more heart attacks among people who took both drugs. This evidence is limited, though, and some trials have suggested there may not be an issue. If you have concerns, speak to your doctor.

❓ Are H2 blockers safer than PPI?

👉 If you had to choose between long-term PPI use or long-term H2 blocker use, the H2 blocker would be the safer bet. H2 blockers reduce stomach acidity to a much lesser extent while maintaining the stomach's ability to react to internal stimuli and change the acidity as needed.

❓ Do stomach acid blockers increase the risk of death?

👉 Popular stomach acid blockers linked to higher death rates. A higher risk of death is associated with long-term use of popular stomach acid reducers known as proton pump inhibitors, according to a new study.

❓ Could common heartburn drugs raise death risks?

👉 THURSDAY, June 6, 2019 (HealthDay News) -- People who use common heartburn drugs for months to years may face heightened risks of dying from heart disease, kidney failure or stomach cancer, a new study suggests. The study included more than 200,000 U.S. veterans. It's the latest to raise concerns over drugs called proton pump inhibitors (PPIs).

❓ What are the long-term effects of acid blockers?

👉 Long-term use of acid blockers causes severe nutrient deficiencies and exacerbates leaky gut and food allergies. Acid blockers don’t allow the digestive process to proceed normally. The stomach should signal to the small intestine that food, now a paste called chyme, is ready to be further broken down by pancreatic enzymes and bile.

❓ What are the side effects of taking an acid reducer?

👉 Side effects. Since stomach acid kills pathogenic bacteria, use of acid reducers also has been linked to increased rates of food poisoning. A 2015 study led by Stanford University researchers found that use of PPIs, but not H2 blockers, is associated with higher risk of heart attacks.

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